The genetic pathways of head and neck cancer
09-10, 15:00–16:00 (Europe/Istanbul), Humanitarian + Transverse Activities + Global Outreach

<p>Description</p> <p>This session reviews the critical molecular landscape of head and neck squamous cell carcinoma (HNSCC). We will examine key genetic alterations and signaling pathways, including TP53, NOTCH1, and EGFR/PI3K. The presentation highlights how these genetic drivers influence tumor progression, metastasis, and resistance to current treatment modalities, offering a snapshot of the current genomic understanding of the disease.</p> <p>Outcome Objectives</p> <p>1. Identify major genetic mutations and chromosomal alterations associated with head and neck cancer.<br>2. Understand the relationship between specific genetic pathways and clinical disease behavior.<br>3. Evaluate the potential of these genetic pathways as targets for future precision medicine and therapeutic interventions.</p> <p>Background</p> <p>Head and neck cancer exhibits significant molecular heterogeneity, which often complicates treatment and prognosis. While traditional risk factors are well-known, the underlying genetic mechanisms driving carcinogenesis are complex. Elucidating these genetic pathways is essential for developing novel biomarkers and targeted therapies, ultimately aiming to improve survival rates and reduce treatment-related morbidity.</p>
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Moderator-Speaker Moderator-Speaker
<p>He was born in 1987 in Istanbul. He graduated from Hacettepe University Faculty of Medicine in 2012. He completed her specialty education in Istanbul University Cerrahpaşa Faculty of Medicine, Department of Otorhinolaryngology in 2017. He completed her compulsory service at Erzincan Binali Yıldırım University Mengücek Gazi Training and Research Hospital Otorhinolaryngology Clinic between 2017-2020. In 2020, He started working as a lecturer doctor in the Department of Otorhinolaryngology, Bursa Uludag University Faculty of Medicine, and he still continues to work. In 2017, he successfully passed the written and oral exams organized by the Turkish Otorhinolaryngology and Head and Neck Surgery Board and received the Certificate of Competence. In 2019, he worked as observer at the University of Texas MD Anderson Cancer Hospital in the United States for 1 month. He was awarded the title of Fellow of the European Board of ORL-HNS (FEBORL-HNS) by being successful in the written and oral exam he also entered in 2019.</p>
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<p>Seda Türkoğlu Babakurban, MD, PhD, is full Associate Professor in the Departmet of Otorhinolaryngology-Head and Neck Surgery of Baskent University of Medical Faculty, Turkey. She is also an academic member of the Department of Medical Genetics of Baskent University of Medical Faculty, Turkey. She received her MD degree at the University of Hacettepe, Turkey in 2003 and completed her residency programme in OHNS Department of Baskent University Medical Faculty in 2009. She became Professor in 2023. She received her PhD degree in Medical Biology in 2018. Her clinical and research activities are especially focused on head and oncology and tumor biology. She is an active member of Turkish Head and Neck Society and European Head and Neck Society. She authored or co-authored in 50 international/national journal papers.</p>
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<p>Elif Ersoy Çallıoğlu is an Otolaryngology–Head and Neck Surgery specialist at Ankara Bilkent City Hospital. She has graduated from Ege University Faculty of Medicine in 2000 and completed his residency training in Otolaryngology–Head and Neck Surgery at the same university in 2005. She served as an observer at the pittshburg university , focusing on head and neck surgery and robotic surgery. She was awarded the title of Associate Professor in 2020.</p> <p>Dr. Ersoy Çallıoğlu has contributed chapters to both international and national books. She has presented her research at national and international conferences and has received awards at both levels. She has authored and co-authored great number of publications. She has served in various roles for numerous journals, including as an advisory board member and reviewer. She is a member of several national and international societies. Her main interests include head and neck surgery, transoral laser surgery (including laryngectomy procedures), transoral robotic surgery, and thyroid surgery</p>
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