Description

This session reviews the critical molecular landscape of head and neck squamous cell carcinoma (HNSCC). We will examine key genetic alterations and signaling pathways, including TP53, NOTCH1, and EGFR/PI3K. The presentation highlights how these genetic drivers influence tumor progression, metastasis, and resistance to current treatment modalities, offering a snapshot of the current genomic understanding of the disease.

Outcome Objectives

1. Identify major genetic mutations and chromosomal alterations associated with head and neck cancer.
2. Understand the relationship between specific genetic pathways and clinical disease behavior.
3. Evaluate the potential of these genetic pathways as targets for future precision medicine and therapeutic interventions.

Background

Head and neck cancer exhibits significant molecular heterogeneity, which often complicates treatment and prognosis. While traditional risk factors are well-known, the underlying genetic mechanisms driving carcinogenesis are complex. Elucidating these genetic pathways is essential for developing novel biomarkers and targeted therapies, ultimately aiming to improve survival rates and reduce treatment-related morbidity.

Description: This presentation will explore the evolving role of partial laryngectomy in the treatment of T3 laryngeal cancer within the framework of contemporary organ preservation strategies. While concurrent chemoradiotherapy has become the preferred modality for many patients, particularly in an effort to preserve laryngeal function, surgical options such as partial laryngectomy remain highly relevant in selected cases. Through clinical evidence and case-based discussion, this session will highlight the indications, technical considerations, and outcomes of partial laryngectomy in the modern era.

Outcome Objectives: Understand the rationale behind organ preservation strategies in T3 laryngeal cancer and their current place in treatment guidelines. Identify the clinical and anatomical criteria that make a patient a candidate for partial laryngectomy. Compare the oncological and functional outcomes of partial laryngectomy versus non-surgical approaches such as chemoradiotherapy. Integrate multidisciplinary perspectives when evaluating treatment options for advanced laryngeal cancer.

Background: The management of T3 laryngeal cancer has significantly evolved over the past two decades, with a marked shift toward organ-preserving chemoradiotherapy protocols. While these approaches can successfully maintain the anatomical integrity of the larynx, they do not always guarantee preservation of its function and may be associated with long-term toxicity. In selected patients, partial laryngectomy offers an alternative that not only achieves local control but also provides favorable functional outcomes. However, the use of partial surgery has declined in clinical practice, often due to overgeneralization of non-surgical strategies. This presentation aims to revisit and recontextualize the role of partial laryngectomy in light of current evidence and patient-centered care considerations.

Postoperative delirium is a state of confusion and cognitive impairment that can be observed after extensive surgery. This serious complication can lead to longer hospital stays and higher costs. As the global population ages, postoperative delirium has also become a concern for patients undergoing head and neck surgery. In this study, we investigated whether the preoperative recognition of cognitive impairment could help with the prediction of postoperative delirium among patients undergoing head and neck surgery.

Endolaryngeal laser surgery is an effective treatment modality in the management of in situ and early stage laryngeal carcinoma

Transoral laser surgery has an important place in early stage laryngeal cancers. Preoperative endoscopic and radiological evaluation of patients is important. Especially in glottic tumors, anterior commissure involvement is a poor prognostic criterion.