Fatih Tetik
Dr. Fatih Tetik was born in Izmir, Türkiye, in 1986. He graduated from Istanbul University Cerrahpaşa Faculty of Medicine in 2010 and completed his residency training in Otorhinolaryngology–Head and Neck Surgery at Şişli Hamidiye Etfal Training and Research Hospital in 2016. After completing his compulsory service at Uşak Training and Research Hospital, he joined the Department of Otorhinolaryngology–Head and Neck Surgery at University of Health Sciences, Gaziosmanpaşa Training and Research Hospital, Istanbul, in 2021, where he currently works as an ENT specialist and Chief Assistant. He received the Turkish Otorhinolaryngology–Head and Neck Surgery Board Certificate of Competence in 2018. His main clinical and academic interest is head and neck oncology, with a particular focus on head and neck tumors.
Session
Description
this session reviews the critical molecular landscape of head and neck squamous cell carcinoma (HNSCC). We will examine key genetic alterations and signaling pathways, including TP53, NOTCH1, and EGFR/PI3k. The presentation highlights how these genetic drivers influence tumor progression, metastasis, and resistance to current treatment modalities, offering a snapshot of the current genomic understanding of the disease.
outcome objectives
identify major genetic mutations and chromosomal alterations associated with head and neck cancer.
understand the relationship between specific genetic pathways and clinical disease behavior.
evaluate the potential of these genetic pathways as targets for future precision medicine and therapeutic interventions.
background
head and neck cancer exhibits significant molecular heterogeneity, which often complicates treatment and prognosis. While traditional risk factors are well-known, the underlying genetic mechanisms driving carcinogenesis are complex. Elucidating these genetic pathways is essential for developing novel biomarkers and targeted therapies, ultimately aiming to improve survival rates and reduce treatment-related morbidity.