Frontiers in vestibular research
09-12, 07:30–08:00 (Europe/Istanbul), Equilibrium 2

<p>We will introduce the latest findings from clinical research on Meniere's disease and benign paroxysmal positional vertigo, as well as the latest findings from basic research on hair cells in the otolith organs</p> <p>Meniere disease</p> <p>Vertiginous symptoms in patients with Meniere's disease (MD) are weather-related. Endolymphatic hydrops (EH) have been thought to be the pathological basis of MD. Endolymphatic space (ELS) volume can be evaluated using three-dimensional analysis of 3-Tesla magnetic resonance imaging after intravenous injection of gadolinium enhancement. In patients with developed MD (average hearing levels in the affected ear of 40-70 dB), a significant negative correlation was found between atmospheric pressure change and vestibular ELS rate on the affected side. Negative atmospheric pressure changes may influence vestibular ELS volume in patients with moderate hearing impairment</p> <p>Benign paroxysmal positional vertigo (BPPV)</p> <p>Posterior canal-type benign paroxysmal positional vertigo (pc-BPPV) is diagnosed when positional torsional nystagmus is induced by the Dix-Hallpike test (DHT). When the DHT is repeated, positional nystagmus disappears. This phenomenon is known as BPPV fatigue. In cases where positional nystagmus cannot be induced by the DHT because of BPPV fatigue occurring just before a medical examination, or where positional nystagmus is not observed during the first DHT, we cannot make a diagnosis of pc-BPPV because the DHT can no longer induce the positional nystagmus typical of pc-BPPV. We have succeeded to develop a new maneuver to rapidly restore positional nystagmus in cases of BPPV fatigue, thereby facilitating accurate diagnosis</p> <p>Modulation of the physiological function of hair cells in saccule</p> <p>We investigate the influence of myosin regulatory light chain and myosin light chain kinase on the physiological function of inner ear hair cells. We confirmed the expression of NM2A/B and MYL9 on the apical surfaces of hair cells and of NM2A and MYL12A in hair bundles. We found that NM2 and MLCK inhibitors reduce the stiffness of hair bundles from the bullfrog's saccule. Moreover, MLCK inhibition inhibits the spontaneous oscillation of hair bundles and increases the resting open probability of transduction channels. In addition, MLCK inhibition elevates hearing thresholds in mice. We conclude that NM2 and the phosphorylation of RLC modulate the physiological function of hair cells and thereby help to set the normal operating conditions of hair bundles.</p>
<p>The purpose of this round table is to introduce the latest findings from clinical research on Meniere's disease and benign paroxysmal positional vertigo, as well as the latest findings from basic research on hair cells in the otolith organs.</p>
Session Chair Session Chair
Levent Naci Özlüoğlu
Speaker Speaker
Takao Imai
Takao Imai
<p>Personal Information</p> <p>Title MD, PhD</p> <p>Name Takao Imai</p> <p>Country Japan</p> <p>Affiliation Center for Ear Surgery and Dizziness & Hearing Loss Treatment, Bellland General Hospital</p> <p>Academic appointments</p> <p>Director of the center 2022-present</p> <p>Center for Ear Surgery, Dizziness & Hearing Loss Treatment, Bellland General Hospital, Osaka, Japan</p> <p>Associate professor 2019-2022</p> <p>Dept. of Otorhinolaryngology, Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan</p> <p>Lecturer 2014-2019</p> <p>Dept. of Otorhinolaryngology, Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan</p> <p>Assistant Professor 2009-2014</p> <p>Dept. of Otorhinolaryngology, Head and Neck Surgery, Osaka University Graduate School of Medicine, Osaka, Japan</p> <p>Instructor 2001-2007</p> <p>Dept. of Otolaryngology, Kansai Rosai Hospital, Hyogo, Japan</p> <p>Professional Societies</p> <p>International</p> <p>Barany Society (Active Member) 2012-present</p> <p>Domestic</p> <p>Director of Japan Society For Equilibrium Research 2021-present</p>
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Levent Naci Özlüoğlu
<p>ISTANBUL UNIVERSITY, CERRAHPASA MEDICAL SCHOOL, 1981</p> <p>HACETTEPE MEDICAL SCHOOL, DEPARTMENT OF OTOLARYNGOLOGY, 1987</p> <p>BAYLOR COLLEGE OF MEDICINE, DEPARTMENT OF ORL, NEUROTOLOGY FELLOWSHIP TX, USA 1993</p> <p>INONU UNIVERSITY SCHOOL OF MEDICINE, DEP OF ORL MALATYA, 1996</p> <p>BASKENT UNIVERSITY SCHOOL OF MEDICINE, DEP. OF ORL. CHAIRMAN, ANKARA SINCE 1996</p>
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