Giovanni Succo
.ical

<p>Otorhinolaryngologist and Surgical Oncologist</p> <p>Full Professor Otolaryngology/Head and Neck Surgery – Dept. Oncology – University of Turin</p> <p>Chair Otolaryngology/Head and Neck Unit - San Giovanni Bosco Hospital – Turin</p> <p>President of European Head and Neck Society</p> <p>President of Italian University Society of Otolaryngology</p> <p>Past President of Italian Head and Neck Society</p> <p>Author of 147 peer reviewed papers and many book chapters mainly focused on laryngeal oncology, partial laryngectomies and, the last ones, on mini-invasive 3D exoscopic surgery.</p>
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Sessions

09-10
14:00
30min
20 Years of Supratracheal Laryngectomy: A Comprehensive Review and Future Perspectives
Utku Aydil, Giovanni Succo
Head and Neck Oncology
Head & Neck Oncology 2
09-10
14:30
60min
Management of intermediate and advanced laryngeal cancer (T3-T4)
Utku Aydil, Giovanni Succo, Dusan  Milisavljevic, Marco De Vincentiis, Vladimir Pavićević, Basim Wahba
Head and Neck Oncology
Head & Neck Oncology 2
09-12
10:45
60min
Head and neck Cancer International Group (HNCIG) session: Trials and tribulations of trials: lessons learnt and practical tips
Hisham Mehanna, Christian Simon, Giovanni Succo

This panel will include presentations on:

1. The pros and cons of real-world data studies

2. Planning and executing successful real-world data studies: The HNCIG EPIC study.

3. Multi-centre, multi-national data collection: The HNCIG and RedCap data bases.

4. Example of Real-world data studies by Young Investigators

5. Panel discussion and question and answers.

Head and Neck Oncology
Head & Neck Oncology 1
09-12
15:00
60min
EHNS Tumor Board
Şefik Hoşal, Senada Koljenović, Mustafa Cengiz, Giovanni Succo, Mario Fernandez, Jan Klozar
Head and Neck Oncology
Head & Neck Oncology 1
09-12
17:00
60min
Feasibility of functional preservation surgery of T3/T4 head and neck cancer - a pirouette around the cricoarytenoid joint
Todor Popov, Jerome LECHIEN, Giovanni Succo, Andy Bertolin- Italy, Dusan  Milisavljevic, Andrea Iandelli

Description: This proposal is focused on discussing the surgical feasibility of laryngeal preservation in advanced T3/T4 head and neck cancer, using the cricoarytenoid joint status as the primary assessment criterion. It is based on a a prospective, monocentric study conducted from 2020 to 2023, involving 162 patients with advanced T3/T4 squamous cell carcinoma of the head and neck. The study also assessed survival and dysphagia outcomes. Laryngeal preservation was feasible in 88% of cases when the cricoarytenoid joint was not invaded. No significant difference in recurrence-free survival was found between the laryngectomy and larynx preservation groups (78.9% vs. 85.1% recurrence-free rates). Transoral surgery resulted in faster recovery than open surgery (p = 0.001) and better overall survival (92.6% vs. 70.0%, p = 0.38). Long-term dysphagia levels and recurrence-free survival rates were similar between different surgical approaches.

Outcome Objectives: Define the theoretically possible limits for surgical preservation of the larynx and explore the possibilities of preservation surgery in advanced head and neck carcinoma beyond the theoretical red line of cricoarytenoid invasion in all directions.

1. Popov et al. Large monocentric prospective study on feasibility of functional preservation surgery of T3/T4 head and neck cancer - a pirouette around the cricoarytenoid joint. (under review)
2. Popov et al. Oncological outcomes of primary laryngectomy in T4 laryngopharyngeal cancer – study of 76 cases. Laryngorhinootologie 2019; 98(S 02): S80DOI: 10.1055/s-0039-1686049
3. Popov, T.M., Stancheva, G., Kyurkchiyan, S.G. et al. Global microRNA expression profile in laryngeal carcinoma unveils new prognostic biomarkers and novel insights into field cancerization. Sci Rep 12, 17051 (2022). https://www.nature.com/articles/s41598-022-20338-w

Head and Neck Oncology
Head & Neck Oncology 3