Giovanni Succo
Otorhinolaryngologist and Surgical Oncologist
Full Professor Otolaryngology/Head and Neck Surgery – Dept. Oncology – University of Turin
Chair Otolaryngology/Head and Neck Unit - San Giovanni Bosco Hospital – Turin
President of European Head and Neck Society
President of Italian University Society of Otolaryngology
Past President of Italian Head and Neck Society
Author of 147 peer reviewed papers and many book chapters mainly focused on laryngeal oncology, partial laryngectomies and, the last ones, on mini-invasive 3D exoscopic surgery.
Sessions
This panel will include presentations on:
1. The pros and cons of real-world data studies
2. Planning and executing successful real-world data studies: The HNCIG EPIC study.
3. Multi-centre, multi-national data collection: The HNCIG and RedCap data bases.
4. Example of Real-world data studies by Young Investigators
5. Panel discussion and question and answers.
Description: This proposal is focused on discussing the surgical feasibility of laryngeal preservation in advanced T3/T4 head and neck cancer, using the cricoarytenoid joint status as the primary assessment criterion. It is based on a a prospective, monocentric study conducted from 2020 to 2023, involving 162 patients with advanced T3/T4 squamous cell carcinoma of the head and neck. The study also assessed survival and dysphagia outcomes. Laryngeal preservation was feasible in 88% of cases when the cricoarytenoid joint was not invaded. No significant difference in recurrence-free survival was found between the laryngectomy and larynx preservation groups (78.9% vs. 85.1% recurrence-free rates). Transoral surgery resulted in faster recovery than open surgery (p = 0.001) and better overall survival (92.6% vs. 70.0%, p = 0.38). Long-term dysphagia levels and recurrence-free survival rates were similar between different surgical approaches.
Outcome Objectives: Define the theoretically possible limits for surgical preservation of the larynx and explore the possibilities of preservation surgery in advanced head and neck carcinoma beyond the theoretical red line of cricoarytenoid invasion in all directions.
Popov et al. Large monocentric prospective study on feasibility of functional preservation surgery of T3/T4 head and neck cancer - a pirouette around the cricoarytenoid joint. (under review)
Popov et al. Oncological outcomes of primary laryngectomy in T4 laryngopharyngeal cancer – study of 76 cases. Laryngorhinootologie 2019; 98(S 02): S80DOI: 10.1055/s-0039-1686049
Popov, T.M., Stancheva, G., Kyurkchiyan, S.G. et al. Global microRNA expression profile in laryngeal carcinoma unveils new prognostic biomarkers and novel insights into field cancerization. Sci Rep 12, 17051 (2022). https://www.nature.com/articles/s41598-022-20338-w