Description

This session reviews the critical molecular landscape of head and neck squamous cell carcinoma (HNSCC). We will examine key genetic alterations and signaling pathways, including TP53, NOTCH1, and EGFR/PI3K. The presentation highlights how these genetic drivers influence tumor progression, metastasis, and resistance to current treatment modalities, offering a snapshot of the current genomic understanding of the disease.

Outcome Objectives

1. Identify major genetic mutations and chromosomal alterations associated with head and neck cancer.

2. Understand the relationship between specific genetic pathways and clinical disease behavior.

3. Evaluate the potential of these genetic pathways as targets for future precision medicine and therapeutic interventions.

Background

Head and neck cancer exhibits significant molecular heterogeneity, which often complicates treatment and prognosis. While traditional risk factors are well-known, the underlying genetic mechanisms driving carcinogenesis are complex. Elucidating these genetic pathways is essential for developing novel biomarkers and targeted therapies, ultimately aiming to improve survival rates and reduce treatment-related morbidity.