Objectives: to summarize the current literature for epidemiology, clinical management, and treatment of laryngopharyngeal reflux disease (LPRD).

Methods: Based on a PRISMA systematic search of literature, the author will provide an EBM practice for general otolaryngologists and laryngologists for the management of LPRD. A special focus will be done on the definition of LPRD, the decision to perform objective additional examination (hypopharyngeal-esophageal impedance-pH testing) or empirical therapeutic trial, the method for assessing the treatment responses, and the best therapeutic regimens. At the end of the keynote lecture, the audience should manage primary and recalcitrant LPRD.