09-11, 17:30–18:00 (Europe/Istanbul), Rhinology 4 (ICC - 3B/13)
Aims: This study examined the frequency of comorbidities in patients with respiratory epithelial adenomatoid hamartoma (REAH) and determined whether comorbidity affects the clinical characteristics of REAH.
Methods: A retrospective cohort study included patients with REAH who had been treated and followed up over 15 years. Clinical parameters included the side of the nasal cavity, localization and size of the lesion, duration of symptoms, and associated chronic inflammation.
Results: Twenty (n = 20) patients with REAH were included. We found an association of REAH with chronic sinonasal inflammatory disorders in 70% of cases: in 30% with perennial allergic rhinitis (PAR), in 25% with chronic rhinosinusitis with nasal polyps (CRSwNP), and in 15% of cases with aspirin-exacerbated respiratory disease (AERD). In 87.5% of cases of bilateral REAH, the lesion was associated with inflammatory nasal polyps, in 80% of patients with CRSwNP as a comorbidity, and in 100% of patients when it was AERD. Symptoms were longer in REAH patients with associated sinonasal inflammation (P ˂ 0.038). We had a far greater average volume of REAH in patients with AERD than in cases with PAR, and CRSwNP (P ˂ 0.001; P ˂ .001, respectively). A positive correlation was found between the duration of symptoms and the lesion volume (R = 0.700; P = 0.001).
Conclusion: A high degree of association between REAH and chronic sinonasal inflammation was found. The results also suggest that inflammation in AERD is the strongest provoking factor for the growth of REAH. A direct correlation was observed between the duration of nasal symptoms and the lesion size.
This study examined the frequency of comorbidities in patients with respiratory epithelial adenomatoid hamartoma (REAH) and determined whether comorbidity affects the clinical characteristics of REAH.
Full Professor of Otorhinolaryngology at the Faculty of Medicine of the Military Medical Academy.
Engaged in the research of pathophysiological mechanisms in chronic inflammatory diseases of the nasal and paranasal sinuses mucosa and rhinogenic headache, as well as those related to the use of herbal drugs in the treatment of rhinosinusitis. In clinical work, he deals with functional and esthetic surgery of the nose, as well as endoscopic surgery of the nasal cavity and paranasal sinuses.
He has published many papers in international peer-reviewed journals, mostly in CC/SCI/SCIE (Web of Science) journals. He is a reviewer for many international peer-reviewed journals.
He is a member of the European Rhinologic Society (ERS), the ENT Section of the European Academy of Allergy & Clinical Immunology (EAACI), and the ENT Section of the Serbian Medical Society.
Since 2015, he has been the President of the Rhinology & Allergy Association of Serbia. Since 2023, he has been the Serbian representative in the European Rhinologic Society.
