<p>Management of recurrent nasopharyngeal carcinoma, from diagnosis to potential complications.</p>
<p>Locally recurrent nasopharyngeal carcinoma (NPC) presents substantial challenges in clinical management so that a multimodal approach is needed. Endoscopic endonasal approach has been reported in the early 2000s as a potential treatment for selected and, nowadays, endoscopic nasopharyngectomy is regarded as the preferred option for resectable locally recurrent NPC</p>
<p>An italian multicenter retrospective review of patients with recurrent NPC, treated with pure endoscopic approach in tertiary referral center.</p>
<p>We report an analysis of the algorithm used to reach the relapse diagnosis, how patients selection was performed, oncological results and complications related to the treatments and their management. A particular emphasis is placed upon carotid artery preoperative management and skull base osteomyelitis as a possible post-operative complication.</p>
<p>Recurrent NPS is a challenging disease. Only a proper patients selection and a 360° patients management is necessary to achieve optimal oncological outcomes</p>