<p>Background</p>
<p>Laryngeal preservation has become a central goal in the management of locally-advanced larynx cancer, supported by a growing body of comparative evidence between transoral laser microsurgery, open conservative surgery, radiotherapy, and chemoradiation. However, real-world practice remains highly variable, and treatment decisions are often influenced by local expertise, inconsistent interpretation of staging, and limited understanding of functional trade-offs. An evidence-based, practical framework is essential to guide clinicians in selecting the most appropriate modality for each patient.</p>
<p>Description</p>
<p>This instructional course provides a comprehensive and evidence-based overview of current laryngeal preservation strategies for locally advanced laryngeal cancer, integrating surgical and non-surgical approaches. Through comparative outcome data, decision-making algorithms, and case-based discussion, the course will highlight how to select the most appropriate treatment for each clinical scenario. The session is designed to offer a practical framework applicable to everyday clinical practice across different healthcare settings.</p>
<p>Outcomes Objectives</p>
<p>- Identify evidence-based indications and contraindications for the main laryngeal preservation modalities, including transoral laser surgery, open partial laryngectomy, radiotherapy, and chemoradiation.<br>- Compare oncologic, functional, and quality-of-life outcomes across treatment options, and apply this information in individualized treatment planning.<br>- Recognize limitations, risks, and common pitfalls in patient selection and in multimodal management strategies.<br>- Integrate evidence-driven algorithms into clinical decision-making to optimize both tumor control and functional preservation.</p>
<p>This instructional course will synthesize the current evidence on oncologic control and functional outcomes across surgical and non-surgical laryngeal preservation strategies. The aim is to clarify indications and contraindications, highlight the limitations of each approach, and provide clinicians with realistic expectations to communicate to patients.</p>
<p>Participants will review comparative outcome data, landmark trials, recent meta-analyses, and evolving trends in functional assessment. Case-based discussions will illustrate the application of evidence to real clinical scenarios, emphasizing proper patient selection, predictors of success, and management of treatment-related dysfunctions.</p>
