BEGIN:VCALENDAR VERSION:2.0 PRODID:-//pretalx//sciencenext.org//ifos2026//ZTTSHQ BEGIN:VTIMEZONE TZID:EET BEGIN:STANDARD DTSTART:20001029T030000 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10;UNTIL=20061029T000000Z TZNAME:EET TZOFFSETFROM:+0300 TZOFFSETTO:+0200 END:STANDARD BEGIN:STANDARD DTSTART:20071028T050000 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10;UNTIL=20141026T020000Z TZNAME:EET TZOFFSETFROM:+0300 TZOFFSETTO:+0200 END:STANDARD BEGIN:STANDARD DTSTART:20151108T050000 RRULE:FREQ=YEARLY;BYDAY=2SU;BYMONTH=11;UNTIL=20151108T020000Z TZNAME:EET TZOFFSETFROM:+0300 TZOFFSETTO:+0200 END:STANDARD BEGIN:STANDARD DTSTART:20160907T010000 RRULE:FREQ=YEARLY;BYDAY=1WE;BYMONTH=9 TZNAME:+03 TZOFFSETFROM:+0300 TZOFFSETTO:+0300 END:STANDARD BEGIN:DAYLIGHT DTSTART:20000326T020000 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3;UNTIL=20060326T000000Z TZNAME:EEST TZOFFSETFROM:+0200 TZOFFSETTO:+0300 END:DAYLIGHT BEGIN:DAYLIGHT DTSTART:20070325T040000 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3;UNTIL=20100328T020000Z TZNAME:EEST TZOFFSETFROM:+0200 TZOFFSETTO:+0300 END:DAYLIGHT BEGIN:DAYLIGHT DTSTART:20110328T040000 RRULE:FREQ=YEARLY;BYDAY=4MO;BYMONTH=3;UNTIL=20110328T020000Z TZNAME:EEST TZOFFSETFROM:+0200 TZOFFSETTO:+0300 END:DAYLIGHT BEGIN:DAYLIGHT DTSTART:20120325T040000 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3;UNTIL=20130331T020000Z TZNAME:EEST TZOFFSETFROM:+0200 TZOFFSETTO:+0300 END:DAYLIGHT BEGIN:DAYLIGHT DTSTART:20140331T040000 RRULE:FREQ=YEARLY;BYDAY=5MO;BYMONTH=3;UNTIL=20140331T020000Z TZNAME:EEST TZOFFSETFROM:+0200 TZOFFSETTO:+0300 END:DAYLIGHT BEGIN:DAYLIGHT DTSTART:20150329T040000 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3;UNTIL=20160327T020000Z TZNAME:EEST TZOFFSETFROM:+0200 TZOFFSETTO:+0300 END:DAYLIGHT END:VTIMEZONE BEGIN:VEVENT UID:pretalx-ifos2026-USVYZE@sciencenext.org DTSTART;TZID=EET:20260910T080000 DTEND;TZID=EET:20260910T083000 DESCRIPTION:

Background and Rational e:

High-definition white light endoscopy (WLE) remains the standard-of-care for evaluating early laryngea l lesions\, providing high-resolution surface and color information. Howev er\, WLE has well-recognized limitations. Early dysplasia may lack clear s urface changes\, while benign inflammatory lesions can mimic malignancy\, resulting in sensitivity values as low as 51% in some studies.

The quintessential clinical dilemma is voc al fold leukoplakia—a descriptive term encompassing a wide histopatholog ical spectrum\, from benign hyperkeratosis to invasive squamous cell carci noma (Piazza et al.\, 2010). Because WLE cannot reliably predict histopath ological severity\, management remains highly controversial. Some clinicia ns advocate routine surgical biopsy due to the risk of occult carcinoma\, while others support conservative observation in low-risk cases (Peretti e t al.\, 2017). This uncertainty results in a significant healthcare burden driven by repeated surveillance\, unnecessary biopsies\, and the risk of delayed diagnosis.

Role of Narr ow Band Imaging (NBI):

NBI has emerged as a critical adjunct by enhancing the visualization of intraepith elial papillary capillary loops (IPCLs)\, thereby improving the detection of neoplastic vascular patterns (Piazza and Peretti\, 2012). Recent litera ture demonstrates a strong correlation between NBI vascular patterns and h istopathological outcomes\, improving diagnostic precision and aiding in t he prediction of malignant transformation in leukoplakia (Lin et al.\, 202 0\; Pietruszewska et al.\, 2021).

Despite its growing acceptance\, NBI is not a panacea. It remains highl y dependent on operator expertise and is subject to diagnostic pitfalls\, particularly in post-radiotherapy mucosa and lesions with deep submucosal extension.

DTSTAMP:20260618T223233Z LOCATION:Phoniatrics 3 SUMMARY:Beyond White Light: The Promise\, Pitfalls\, and Future of NBI in E arly Laryngeal Cancer Detection - Hazem Saleh\, Christoph Arens\, Wioletta Pietruszewska\, Petr Lukes URL:https://sciencenext.org/ifos2026/talk/USVYZE/ END:VEVENT END:VCALENDAR