This keynote will explore how the inner ear and brain respond to microgravity and gravitational transitions during suborbital and orbital flights. A leading scientist and a young researcher will present groundbreaking findings from inner ear physiology and neuroscience in the field of Aerospace. The audience will also be introduced to the newly established SpaceLab near the SpacePort of Grottaglie (Southern Italy), the first international academic centre for research and training in suborbital flight, equipped with both terrestrial and underwater facilities. This session promises a unique glimpse into the frontiers of space medicine and human adaptation beyond Earth.