Treatment approaches in laryngeal cancer
Rogerio A. Dedivitis, Mark Zafereo, Luiz P. Kowalski, Alirio Mijares Brinez, Gabriel Damiano, Paul Boettinger
Early tumors are usually treated with
monotherapy: endoscopic laser resection,
open partial laryngectomy or radiotherapy,
with a good oncological prognosis.
Currently, endoscopic laser resection and
radiotherapy are the preferred options,
with a higher risk of salvage total laryngectomy
and higher treatment costs when radiotherapy
is used. For tumors staged as T3,
if the surgical option is total laryngectomy,
a non-surgical organ preservation protocol
with the combination of radiotherapy and
chemotherapy may be indicated.
With this, in most cases, larynx preservation
is achieved. However, anatomical preservation
often does not correspond to functional preservation.
If the surgical option is partial laryngectomy,
both organ preservation options should
be considered: surgical (partial laryngectomy)
or non-surgical. For more advanced tumors (T4),
total laryngectomy is the option with
the best oncological results, despite the
mutilation caused by the definitive tracheotomy.
The aim of this symposium is to critically discuss
the various therapeutic options for laryngeal cancer.